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KMID : 0370219840280060313
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Yakhak Hoeji
1984 Volume.28 No. 6 p.313 ~ p.319
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Synthesis of Angiotensin Converting Enzyme Inhibitors
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이희주/Lee HJ
김영숙/장영/이종란/윤혜숙/Kim YS/Chang Y/Lee JR/Yun HS
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Abstract
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Phenylurea, phenylthiourea, benzylcarbamate and toluenesulfonate of L-alanyl-L-proline(comp. 3~6) were synthesized and their effects against angiotensin-converting enzyme (ACE) were tested. Comp. 3 showed only mild inhibitory activities against ACE while comp. 4~6 were inert indicating that those functional groups were not suitable for interactions with ACE. Ortho-hydroxy- or ortho-carboxy-benzamide of proline (comp. 7) and phenylalanine (comp. 8 and 9) were also tested. Of the benzamides, ortho-hydroxy function was unsuitable to exert inhibitory activities against ACE. Ortho-carboxy group of 9 seemed to have mild interactions with active site of ACE possibly because of the shorter distance between the amide and ortho-carboxyl group of the compound than the corresponding two active sites of the enzyme.
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KEYWORD
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